Cymbalta treatment, for up to 26 weeks in placebo-controlled trials across approved indications, typically caused a small increase in heart rate for change from baseline to endpoint compared to placebo of up to 1.37 beats per minute (increase of 1.20 beats per minute in Cymbalta -treated patients, decrease of 0.17 beats per minute in placebo-treated patients). Cymbalta is excreted into the milk of lactating women. Possible side effects 5. Table 4 gives the incidence of treatment-emergent adverse events that occurred in 2% or more of patients treated with Cymbalta (determined prior to rounding) in the premarketing acute phase of DPNP, FM, OA, and CLBP placebo-controlled trials and with an incidence greater than placebo. Common side effects include dry mouth, nausea, feeling tired, dizziness, agitation, sexual problems, and increased sweating. Some patients may … It is most commonly prescribed to treat depression and anxiety, although it is also used to treat some forms of pain such as diabetic neuropathic pain and fibromyalgia. The word “melancholia” is a Greek word to describe the feeling of intense sadness and hopelessness. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Common adverse reactions reported as a reason for discontinuation and considered to be drug-related (as defined above) included, dizziness (Cymbalta 1.2%, placebo 0.4%), and. Constipation 2. The most common side effects of Cymbalta (duloxetine) are. Decreased Appetite 3. Cymbalta appears to be associated with concentration-dependent but not clinically meaningful QT shortening. Medicines and their possible side effects can affect individual people in different ways. You may report them to the FDA. Infections and Infestations — Infrequent: gastroenteritis and laryngitis. 3 doctors agree. Cymbalta; Irenka; Descriptions. 1 Withdrawal symptoms . Nearly two-thirds of people with depression do not realize that they have a treatable illness and do not seek treatment. Reactions are categorized by body system according to the following definitions: frequent adverse reactions are those occurring in at least 1/100 patients; infrequent adverse reactions are those occurring in 1/100 to 1/1000 patients; rare reactions are those occurring in fewer than 1/1000 patients. [Ref], Very common (10% or more): Nausea (up to 30%), constipation (up to 15%), dry mouth (up to 15%), vomiting (up to 15%), abdominal pain (up to 13%), diarrhea (up to 13%), Common (1% to 10%): Dyspepsia, flatulence, loose stools, oral paresthesia, stomach discomfort, viral gastroenteritis/gastroenteritis, Uncommon (0.1% to 1%): Dysphagia, eructation, gastritis, gastrointestinal bleeding/hemorrhage, halitosis, stomatitis, Rare (0.01% to 0.1%): Gastric ulcer, hematochezia, microscopic colitis, Frequency not reported: Abdominal discomfort, abdominal tenderness, gastrointestinal pain, lower abdominal pain, upper abdominal pain, Postmarketing reports: Pancreatitis, unspecified colitis[Ref], Very common (10% or more): Somnolence (up to 21%), headache (up to 18%), dizziness (up to 17%), Common (1% to 10%): Dysgeusia, facial hypoesthesia, hypoesthesia, lethargy, paresthesia, psychomotor agitation, tremor, vertigo, Uncommon (0.1% to 1%): Akathisia, attention disturbance, dyskinesia, gait disturbance, myoclonus, poor quality sleep, restless legs syndrome, syncope, Rare (0.01% to 0.1%): Convulsion, dysarthria, extrapyramidal disorder, psychomotor restlessness, serotonin syndrome, Very rare (less than 0.01%): Electric shock-like sensation, seizures, Frequency not reported: Hypersomnia, psychomotor hyperactivity, sedation, sensory disturbances, Postmarketing reports: Intracerebral bleeding[Ref]. Find treatments to ease stress, eliminate worry, and combat anxiety as... Do you feel anxious? Sweating a lot. Childhood depression can interfere with social activities, interests, schoolwork and family life. Send thanks to the doctor. The total warfarin (protein bound plus free drug) pharmacokinetics (AUCτ,ss, Cmax,ss or tmax,ss) for both R-and S-warfarin were not altered by duloxetine. Patients using Cymbalta may experience orgasm problems, such as not being able to reach orgasm or having difficulty reaching orgasm. Commercialisé . Other adverse effects of duloxetine and venlafaxine modified-release include: Drowsiness — may impair performance of skilled tasks such as driving and operating machinery. If Cymbalta or another antidepressant is causing weight changes or other side effects, discuss the options with a doctor. Concomitant administration of duloxetine 40 mg twice daily with fluvoxamine 100 mg, a potent CYP1A2 inhibitor, to CYP2D6 poor metabolizer subjects (n=14) resulted in a 6-fold increase in duloxetine AUC and Cmax. Duloxetine is a medication in the class of anti-depressant drugs, used to treat major depression and provide relief from nerve pain or peripheral neuropathy in diabetics. Anxiety disorders cause worry, fear and panic as an irrational response to mundane situations. Some side effects may not be reported. SSRI’s vs SNRI’s - What's the difference between them? You are encouraged to report negative side effects of prescription drugs to the FDA. According to eMedtv.com, about 6 percent of men and 1 percent of women being treated for … Duloxetine may also make depression worse in the early stages of treatment, and you must alert your doctor immediately if your depression worsens or you have suicidal thoughts. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Visit the FDA MedWatch website or call 1-800-FDA-1088. Falls were more common in patients 65 years and older. by Julia Nelson. We have received so many complaints about duloxetine side effects that we have lost count. Find patient medical information for duloxetine oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Symptoms of withdrawal include. Let those who are around you know about the possible side effects of Cymbalta (duloxetine), so they can help look out for them. Anxiety can occur during everyday life, it could be fleeting or it could persist and build. Following is a list of treatment-emergent adverse reactions reported by patients treated with Cymbalta in clinical trials. The principal types of depression are major depression, dysthymia, and bipolar disease (also called manic-depressive disease). Some of the common side effects of duloxetine will gradually improve as your body gets used to it. Though the holidays are a fun time for most, for others, they're a sad, lonely and anxiety-filled time. Duloxetine, sold under the brand name Cymbalta among others, is a medication used to treat major depressive disorder, generalized anxiety disorder, fibromyalgia, and neuropathic pain. Take duloxetine exactly as your doctor tells you to. [Ref], Very common (10% or more): Fatigue (up to 12%), Common (1% to 10%): Asthenia, chills, falls, feeling jittery, pyrexia, rigors, tinnitus, Uncommon (0.1% to 1%): Ear pain, feeling abnormal, feeling cold/hot, malaise, Frequency not reported: Clinically important drug interactions[Ref]. (1) already listed in previous tables or elsewhere in labeling. If you are experiencing serious medical symptoms, seek emergency treatment immediately. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Sexual dysfunction (decreased sex drive and delayed orgasm and ejaculation) has been associated with Cymbalta (duloxetine). Learn about generalized anxiety disorder (GAD). Hyperglycemia was more commonly reported in patients with diabetes. Diarrhea 4. Some patients may experience withdrawal reactions such anxiety, nausea, nervousness, and insomnia. Trouble sleeping. However, co-administration of duloxetine (60 or 120 mg) with warfarin (2-9 mg), a highly protein-bound drug, did not result in significant changes in INR and in the pharmacokinetics of either total S-or total R-warfarin (protein bound plus free drug). The data described below reflect exposure to Cymbalta in pediatric, 10-week, placebo-controlled trials for MDD (N=341) and GAD (N=135). Additional data come from the overall total of 822 pediatric patients (age 7 to 17 years of age) with 41.7% children age 7 to 11 years of age and 51.8% female exposed to Cymbalta in MDD and GAD clinical trials up to 36-weeks in length, in which most patients received 30-120 mg per day. Only the best antidepressants in our online store with fast worldwide shipping. Depression could happen when there is a decrease in the functional balance of the brain chemicals e.g., serotonin and norepinephrine. In short term, anxiety may cause sleep disturbances and poor work performance. Although not all of these side effects may occur, if they do occur they may need medical attention. Other side effects include: agitation, erectile dysfunction, nervousness, psychomotor agitation, tension, vomiting, abdominal pain, anorexia, decreased appetite, decreased libido, hyperhidrosis, loss of libido, and restlessness. Decreased weight of at least 3.5% occurred more frequently in patients 7 to 17 years of age with GAD and/or MDD. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Common side effects of Cymbalta include nausea, dry mouth, constipation, diarrhea, fatigue, difficulty sleeping, and dizziness, and sexual dysfunction. Dosage for Cymbalta . Duloxetine is also used to treat pain and tingling caused by diabetic neuropathy (damage to nerves that can develop in people who have diabetes) and fibromyalgia (a long-lasting condition that may cause pain, muscle stiffness and tenderness, tiredness, and difficulty falling asleep or staying asleep). [Ref], Very common (10% or more): Insomnia (up to 13%), Common (1% to 10%): Abnormal dreams, abnormal orgasm, agitation, anorgasmia, anxiety, decreased libido, restlessness, sleep disorder, tension, Uncommon (0.1% to 1%): Apathy, bruxism, confusional state, disorientation, irritability, mood swings, nervousness, nightmares, suicidal ideation, suicide attempt, Rare (0.01% to 0.1%): Aggression, anger, completed suicide, hallucinations, mania, suicidal behavior, Frequency not reported: Activation of hypomania, early morning awakening, initial insomnia, intense dreams, loss of libido, middle insomnia, sleep disturbances, terminal insomnia[Ref]. Approximately 13.7% (139/1018) of the patients who received Cymbalta in placebo-controlled trials for GAD discontinued treatment due to an adverse reaction, compared with 5.0% (38/767) for placebo. MedicineNet does not provide medical advice, diagnosis or treatment. Buy Cymbalta online. Cymbalta treatment in placebo-controlled clinical trials across approved indications, was associated with small mean increases from baseline to endpoint in ALT, AST, CPK, and, The effect of Cymbalta 160 mg and 200 mg administered twice daily to steady state was evaluated in a randomized, double-blinded, two-way. Originally produced by Lilly researchers, Duloxetine hydrochloride was patented in 1981 and was approved for use by the Food and Drug Administration (FDA) in 2004. Women did not experience the side effects during these trials. Such side effects of Duloxetine normally do not last long and go away once the treatment is completed. Learn about side effects, dosage, uses, and more. You may have... False ideas scare many depression suffers away from therapy and the quick relief and help these pros can provide. Common adverse reactions reported as a reason for discontinuation and considered to be drug-related (as defined above) included nausea (Cymbalta 3.3%, placebo 0.4%), and dizziness (Cymbalta 1.3%, placebo 0.4%). fiche abrégée DULOXETINE ZENTIVA 60 mg gél gastrorésis. Below is a summary of known side effects for Duloxetine … Contents of the pack and other information. Of these, 26.9% (9337) took Cymbalta for at least 6 months, and 12.4% (4317) for at least one year. Fatigue occurred most frequently in patients given 60 mg orally 2 times a day (N=225); the side effect occurred in 10% of patients given 60 mg orally once a day, and in 2% of patients given 20 mg orally once a day. aspirin, prednisone, trazodone, tramadol, ibuprofen, sertraline, meloxicam, alprazolam, duloxetine, escitalopram. Applies to duloxetine: oral capsule delayed release. The usual dose is one 40 mg capsule twice daily (in the morning and late afternoon). Duloxetine (Cymbalta) is an SNRI antidepressant. Ce médicament est un générique de CYMBALTA. The drug may increase your chances of developing suicidal thoughts and behaviors in those aged 24 or younger. Like most antidepressants, Cymbalta (duloxetine) may trigger suicidal thoughts and behavior in children, adolescents and adults under the age of 24. If you have any of these, see your doctor as soon as possible. Advertisement - Continue Reading Below. The most common side effects of the drug include nausea, headache, dry mouth and sleepiness — but more serious side effects may occur. Seizures have been reported. Since uptake is an important mechanism for removing released neurotransmitters and terminating their actions on adjacent nerves, the reduced uptake caused by Cymbalta increases the effect of serotonin and norepinephrine in the brain. The most commonly observed adverse reactions in Cymbalta-treated patients (as defined above) were nausea, fatigue, constipation, dry mouth, insomnia, somnolence, and dizziness. Duloxetine was investigated for its potential use in treating headaches in a 2007 study, but it was found to have minimal effectiveness. Worth it. The proportion of patients who experienced a clinically significant decrease in weight (≥3.5%) was greater in the Cymbalta group than in the placebo group (14% and 6%, respectively). Learn about warnings, side effects, dosage, and more for duloxetine oral capsule. 0 comment. Anxiety is a feeling of apprehension and fear characterized by symptoms such as trouble concentrating, headaches, sleep problems, and irritability. It will give you more information about duloxetine and will provide you with a full list of the side-effects which you may experience from taking it. But if you have an anxiety disorder, you may feel your anxiety or panic overwhelm you with intense anxiety and fear. 40 mg twice daily, patient should be assessed for benefit and tolerability after 2–4 weeks, alternatively initially 20 mg twice daily for 2 weeks, this can minimise side effects, then increased to 40 mg twice daily, the patient should be assessed for … While height increase was observed during these studies, a mean decrease of 1% in height percentile was observed (decrease of 2% in children [7 to 11 years of age] and increase of 0.3% in adolescents [12 to 17 years of age]). Possible side effects 5. ©1996-2020 MedicineNet, Inc. All rights reserved. Table 3: Treatment-Emergent Adverse Reactions: Incidence of 2% or More and Greater than Placebo in MDD and GAD Placebo-Controlled Trialsa,b. The most commonly observed adverse reactions in Cymbalta-treated patients (as defined above) were nausea, dry mouth, insomnia, somnolence, constipation, dizziness, and fatigue. Uses Cymbalta can treat depression, diabetic neuropathy, fibromyalgia, and other health issues. The drug is sold under the drug name Cymbalta and is officially … Your health care provider is best able to guide your dose taper based on your specific circumstances. Respiratory, Thoracic and Mediastinal Disorders — Frequent: yawning, oropharyngeal pain; Infrequent: throat tightness. 23 thanks. It is taken by mouth. This leaflet should come with your medication (usually inside the box). Substantial intercurrent ethanol use was present in each of these cases, and this may have contributed to the abnormalities seen. We comply with the HONcode standard for trustworthy health information -. Terms of Use. nausea, dry mouth, constipation, diarrhea, fatigue, difficulty sleeping, and; dizziness. In theory, drugs that raise the pH in the gastrointestinal system (for example. Side Effects What are the side effects of Cymbalta (Duloxetine)?. Cymbalta is the brand name for the drug duloxetine. In animal studies, duloxetine did not demonstrate barbiturate-like (depressant) abuse potential. Possible side effects of duloxetine. But most people have no side effects or only minor ones. Nervous System Disorders — Frequent: dysgeusia, lethargy, and paraesthesia/hypoesthesia; Infrequent: disturbance in attention, dyskinesia, myoclonus, and poor quality sleep; Rare: dysarthria. Drug information provided by: IBM Micromedex. Side Effects; Products and services. Neurotransmitters either travel across the space between nerves and attach to receptors on the surface of nearby nerves or they attach to receptors on the surface of the nerves that produce them, to be taken up by the nerve and released again (a process referred to as re-uptake). I have just started taking Duloxetine 30mg each morning and have been feeling awful; really dopey, dizzy and sick. Dizziness 6. Because the safety of Cymbalta in infants is not known, breastfeeding while on Cymbalta is not recommended. Similar effects would be expected with other potent CYP2D6 inhibitors (e.g., fluoxetine, quinidine). That doesn't mean, though, it's normal. How to store Duloxetine Zentiva 6. Other adverse reactions that occurred at an incidence of less than 2% but were reported by more Cymbalta treated patients than placebo treated patients and are associated Cymbalta treatment: Discontinuation-emergent symptoms have been reported when stopping Cymbalta. Excessive Sweating 9. Dans quel cas le médicament DULOXÉTINE ZENTIVA est-il prescrit ? Drug class: serotonin-norepinephrine reuptake inhibitors, Serotonin-norepinephrine reuptake inhibitors, blistering, peeling, or loosening of the skin, hives, itching, puffiness, or swelling of the eyelids or around the eyes, face, lips, or tongue, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, red skin lesions, often with a purple center, sores, ulcers, or white spots in the mouth or on the lips, muscle spasm or jerking of all extremities, talking or acting with excitement you cannot control, difficulty having a bowel movement (stool), change or problem with discharge of semen, feeling of warmth or redness of the face, neck, arms, and occasionally, upper chest, longer than usual time to ejaculation of semen, loss in sexual ability, desire, drive, or performance, shakiness in the legs, arms, hands, or feet, trembling or shaking of the hands or feet. The data below do not include results of the trial examining the efficacy of Cymbalta in patients ≥ 65 years old for the treatment of. Most patients received doses of a total of 60 to 120 mg per day. Swallow the capsule whole and do not crush, chew, break, or open it. Weight loss. Some people may have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. Duloxetine Lilly must not be used together with monoamine oxidase inhibitors (another group of antidepressants), fluvoxamine (another antidepressant), or ciprofloxacin or enoxacin (types of antibiotics). Negative numbers signify an improvement from a baseline level of dysfunction, which is commonly seen in. Far more disturbing are the number of people who tell us how hard it is to discontinue this drug. Famille du médicament : Antidépresseur. Data sources include IBM Watson Micromedex (updated 3 Mar 2021), Cerner Multum™ (updated 1 Mar 2021), ASHP (updated 3 Mar 2021) and others. Cymbalta use during the month before delivery may lead to an increased risk for postpartum hemorrhage and may increase the risk of neonatal complications. Cerner Multum, Inc. "Australian Product Information." Duloxetine capsule increases the levels of serotonin and noradrenaline in the nervous system. These side effects may go away during treatment as your body adjusts to the medicine. Toute reproduction ou représentation totale ou partielle de ce site par quelque procédé que ce … In placebo-controlled clinical trials across approved indications for change from baseline to endpoint, Cymbalta treatment was associated with mean increases of 0.23 mm. Some duloxetine overdose symptoms seem like the same kinds of regular mild-to-moderate side effects of duloxetine doctors discuss with their patients before prescribing the drug. Table 3 gives the incidence of treatment-emergent adverse reactions in MDD and GAD placebo-controlled trials for approved indications that occurred in 2% or more of patients treated with Cymbalta and with an incidence greater than placebo. Learn simple... 10 holiday depression and stress triggers, and ways to cope. Free E-newsletter Subscribe to Housecall. Patients more youthful compared to 24 will need to be kept track of for negative side effects at the beginning of the procedure, as a handful of patients making use of Cymbalta developed some symptoms that threatened. Table 2: Treatment-Emergent Adverse Reactions: Incidence of 5% or More and Greater than Placebo in Placebo-Controlled Trials of Approved Indicationsa. The best pharmacy offers for Cymbalta. Some patients may experience withdrawal reactions upon stopping Cymbalta (duloxetine). Such symptoms include lightheadedness, drowsiness, or dizziness. Treatment may involve psychotherapy and medication. The following adverse reactions have been identified during post-approval use of Cymbalta. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Welcome to Our Website! The most common side effects of Cymbalta (duloxetine) are. So I tried taking it at night, but it leads to restless sleep (though I might fall asleep more quickly). Therefore, an increase in the metabolism of CYP1A2 substrates (e.g.. Duloxetine is a moderate inhibitor of CYP2D6. Lower the dose. Duloxetine :: Side Effects And Withdrawal Symptoms Aug 2, 2014. Learn about the symptoms, diagnosis... Depression can cause physical problems such as insomnia, chest pain, fatigue, headaches, and more. Drugs that raise the gastrointestinal pH may lead to an earlier release of duloxetine. Or when you don't see the sun for a while? Get emergency medical help if you have signs of an allergic reaction to duloxetine (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Buy Duloxetine used to treat depression and anxiety, to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to conditions such as arthritis, chronic back pain, or fibromyalgia (a condition causes widespread pain). We have received so many complaints about duloxetine side effects that we have lost count. https://www.forhers.com/blog/duloxetine-cymbalta-side-effects [Ref], Common (1% to 10%): Hyperhidrosis/increased sweating, pruritus, rash, Uncommon (0.1% to 1%): Cold sweat, contact dermatitis, erythema, night sweats, photosensitivity reaction, urticaria, Very rare (less than 0.01%): Cutaneous vasculitis, contusion, Stevens-Johnson syndrome, Frequency not reported: Severe skin reactions, subcutaneous tissue disorder[Ref], Uncommon (0.1% to 1%): Diplopia, dry eye, mydriasis, visual impairment, Frequency not reported: Angle-closure glaucoma[Ref], Uncommon (0.1% to 1%): Acute liver injury, ALT elevation, alkaline phosphatase elevation, AST elevation, blood bilirubin increased, elevated liver enzymes, GGT increased, hepatitis, Rare (0.01% to 0.1%): Hepatic failure, jaundice, Frequency not reported: Hepatotoxicity, liver failure[Ref], Rare (0.01% to 0.1%): Hyperprolactinemia, syndrome of inappropriate antidiuretic hormone secretion (SIADH)[Ref], Uncommon (0.1% to 1%): Hypersensitivity disorder, Rare (0.01% to 0.1%): Anaphylactic reaction, Very rare (less than 0.01%): Angioneurotic edema, hypersensitivity[Ref], Uncommon (0.1% to 1%): Increased tendency to bruise, Postmarketing reports: Abnormal bleeding events, blood dyscrasias[Ref], Postmarketing reports: Renal dysfunction[Ref], 1. Low Energy 10. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Signs, Symptoms, and Side Effects of Cymbalta (Duloxetine) Abuse Cymbalta is the brand-name version of duloxetine, which is a “dual-inhibitor” SNRI-type antidepressant . These side effects may go away during treatment as your body adjusts to the medicine. Side effects not requiring immediate medical attention. Side effects can be mild or severe, temporary or permanent. The most commonly reported symptoms following discontinuation of Cymbalta in pediatric clinical trials have included, Pediatric patients treated with Cymbalta in clinical trials experienced a 0.1kg mean decrease in weight at 10 weeks, compared with a mean. This term is usually used to refer to an intense set of emotions a person experiences in a wide variety of mental illnesses, including depression, stress disorder, and anxiety. There are hundreds of reported Cymbalta side effects but we will focus on the most common ones here (1%-10% or higher) and a number of less common reactions that would signal a high health risk and potentially require swift medical intervention, should they occur. With... Postpartum depression is a treatable medical illness which affects women after giving birth. Duloxetine can have side effects that might affect your sex life. Terms of Use. Cymbalta may cause sexual side effects in some users 1. It is taken by mouth. In general side effects are mild and go away within a few days. Approximately 12.9% (117/906) of the patients who received Cymbalta in placebo-controlled trials for DPNP discontinued treatment due to an adverse reaction, compared with 5.1% (23/448) for placebo. Far more disturbing are the number of people who tell us how hard it is to discontinue this drug. Depression in the elderly is very common. Is This an Emergency? From anxiety over bills to social commitments and travel, WebMD... Do you find yourself getting depressed as winter approaches each year? Side Effects for DULOXETINE HYDROCHLORIDE (duloxetin hydrochloride capsule, delayed release) are also known as adverse reactions. Depression is an illness that involves the body, mood, and thoughts and affects the way a person eats and sleeps, the way one feels about oneself, and the way one thinks about things. Wait it out. Taking duloxetine in higher doses or more often than prescribed will not make it more effective, and may increase side effects. The patient should inform a health care professional if this side effect develops. Cymbalta (duloxetine) is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant used to treat major depressive disorder, generalized anxiety disorder, diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain. Sexual dysfunction (decreased sex drive and delayed orgasm and ejaculation) has been associated with Cymbalta (duloxetine). Concomitant use of duloxetine (40 mg once daily) with paroxetine (20 mg once daily) increased the concentration of duloxetine AUC by about 60%, and greater degrees of inhibition are expected with higher doses of paroxetine. 23-year-old. Serious problems caused by duloxetine are very rare. Approximately 16.5% (99/600) of the patients who received Cymbalta in 13-week, placebo-controlled trials for CLBP discontinued treatment due to an adverse reaction, compared with 6.3% (28/441) for placebo. The six main types are generalized anxiety disorder, panic disorder, social anxiety, separation anxiety, trauma-related disorders and phobias. (3) which were so general as to be uninformative, (4) which were not considered to have significant clinical implications, or. Along with its needed effects, duloxetine may cause some unwanted effects. The most commonly observed adverse reactions in Cymbalta-treated patients (incidence of at least 5% and at least twice the incidence in placebo patients) were, The most commonly observed adverse reactions in Cymbalta-treated patients (as defined above) were, Changes in sexual desire, sexual performance and sexual satisfaction often occur as manifestations of psychiatric disorders or.
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